# Vertex Pharmaceuticals: what changed between 2025-11-10 and 2026-11-10 entity: /record/vertex-pharmaceuticals.md from: 2025-11-10 to: 2026-11-10 page: /record/vertex-pharmaceuticals/diff?from=2025-11-10&to=2026-11-10 json: /v1/entities/vertex-pharmaceuticals/diff?from=2025-11-10&to=2026-11-10 Between 2025-11-10 and 2026-11-10, Vertex Pharmaceuticals's record changed in 18 facts: 3 replaced (net income -$535.6 million → $3.95 billion; operating income -$232.9 million → $4.17 billion; revenue $11.02 billion → $12 billion), 8 added, 7 ended; 11 unchanged. State as of 2025-11-10: /record/vertex-pharmaceuticals.md?as_of=2025-11-10 · as of 2026-11-10: /record/vertex-pharmaceuticals.md?as_of=2026-11-10. Format: subject | predicate | value | valid range | confidence | status | claim. Posts and Hugging Face repos are left out (0 held on 2025-11-10, 0 on 2026-11-10). ## Replaced (3) The same fact with a different value: the claim that held on the earlier day, then the one that holds on the later day. - net income: -$535.6 million → $3.95 billion - [Vertex Pharmaceuticals](/record/vertex-pharmaceuticals.md) | net_income | -535,600,000 United States dollar | valid 2024-12-31 to 2025-12-31 | conf 0.95 | superseded | superseded_by [clm_406C31565DD9](/claim/clm_406C31565DD9.md) | [clm_B3A7B0C585DF](/claim/clm_B3A7B0C585DF.md) sources: https://www.sec.gov/Archives/edgar/data/875320/000087532025000053/0000875320-25-000053-index.htm - [Vertex Pharmaceuticals](/record/vertex-pharmaceuticals.md) | net_income | 3,953,200,000 United States dollar | valid 2025-12-31 to present | conf 0.95 | valid | [clm_406C31565DD9](/claim/clm_406C31565DD9.md) sources: https://www.sec.gov/Archives/edgar/data/875320/000087532026000056/0000875320-26-000056-index.htm - operating income: -$232.9 million → $4.17 billion - [Vertex Pharmaceuticals](/record/vertex-pharmaceuticals.md) | operating_income | -232,900,000 United States dollar | valid 2024-12-31 to 2025-12-31 | conf 0.95 | superseded | superseded_by [clm_08B6F6FEE28A](/claim/clm_08B6F6FEE28A.md) | [clm_33A4466539E6](/claim/clm_33A4466539E6.md) sources: https://www.sec.gov/Archives/edgar/data/875320/000087532025000053/0000875320-25-000053-index.htm - [Vertex Pharmaceuticals](/record/vertex-pharmaceuticals.md) | operating_income | 4,173,300,000 United States dollar | valid 2025-12-31 to present | conf 0.95 | valid | [clm_08B6F6FEE28A](/claim/clm_08B6F6FEE28A.md) sources: https://www.sec.gov/Archives/edgar/data/875320/000087532026000056/0000875320-26-000056-index.htm - revenue: $11.02 billion → $12 billion - [Vertex Pharmaceuticals](/record/vertex-pharmaceuticals.md) | revenue | 11,020,100,000 United States dollar | valid 2024-12-31 to 2025-12-31 | conf 0.95 | superseded | superseded_by [clm_B151EC07FDAE](/claim/clm_B151EC07FDAE.md) | [clm_9011721F7C0D](/claim/clm_9011721F7C0D.md) sources: https://www.sec.gov/Archives/edgar/data/875320/000087532025000053/0000875320-25-000053-index.htm - [Vertex Pharmaceuticals](/record/vertex-pharmaceuticals.md) | revenue | 12,001,300,000 United States dollar | valid 2025-12-31 to present | conf 0.95 | valid | [clm_B151EC07FDAE](/claim/clm_B151EC07FDAE.md) sources: https://www.sec.gov/Archives/edgar/data/875320/000087532026000056/0000875320-26-000056-index.htm ## Added (8) Held on 2026-11-10, not on 2025-11-10. - [Vertex Pharmaceuticals](/record/vertex-pharmaceuticals.md) | agreement | Crinetics Pharmaceuticals, Inc. | valid 2026-07-06 to present | conf 0.95 | valid | [clm_14EDB54D4A3B](/claim/clm_14EDB54D4A3B.md) sources: https://www.sec.gov/Archives/edgar/data/875320/000119312526296710/0001193125-26-296710-index.htm - [Vertex Pharmaceuticals](/record/vertex-pharmaceuticals.md) | cash_and_equivalents | 4,979,300,000 United States dollar | valid 2026-09-30 to present | conf 0.95 | valid | [clm_40B40C0D43E5](/claim/clm_40B40C0D43E5.md) sources: https://www.sec.gov/Archives/edgar/data/875320/000087532026000291/0000875320-26-000291-index.htm - [Vertex Pharmaceuticals](/record/vertex-pharmaceuticals.md) | quarterly_net_income | 653,600,000 United States dollar | valid 2026-09-30 to present | conf 0.95 | valid | [clm_466B90DBA1DE](/claim/clm_466B90DBA1DE.md) sources: https://www.sec.gov/Archives/edgar/data/875320/000087532026000291/0000875320-26-000291-index.htm - [Vertex Pharmaceuticals](/record/vertex-pharmaceuticals.md) | quarterly_operating_income | 712,900,000 United States dollar | valid 2026-09-30 to present | conf 0.95 | valid | [clm_60BA65E99F72](/claim/clm_60BA65E99F72.md) sources: https://www.sec.gov/Archives/edgar/data/875320/000087532026000291/0000875320-26-000291-index.htm - [Vertex Pharmaceuticals](/record/vertex-pharmaceuticals.md) | quarterly_revenue | 3,440,800,000 United States dollar | valid 2026-09-30 to present | conf 0.95 | valid | [clm_30E62BBC7C14](/claim/clm_30E62BBC7C14.md) sources: https://www.sec.gov/Archives/edgar/data/875320/000087532026000291/0000875320-26-000291-index.htm - [Vertex Pharmaceuticals](/record/vertex-pharmaceuticals.md) | shares_outstanding | 253,537,674 shares | valid 2026-10-31 to present | conf 0.95 | valid | [clm_41CC1CCC4C8A](/claim/clm_41CC1CCC4C8A.md) sources: https://www.sec.gov/Archives/edgar/data/875320/000087532026000291/0000875320-26-000291-index.htm - [Vertex Pharmaceuticals](/record/vertex-pharmaceuticals.md) | total_assets | 32,736,300,000 United States dollar | valid 2026-09-30 to present | conf 0.95 | valid | [clm_E8F64842EB2A](/claim/clm_E8F64842EB2A.md) sources: https://www.sec.gov/Archives/edgar/data/875320/000087532026000291/0000875320-26-000291-index.htm - [Vertex Pharmaceuticals](/record/vertex-pharmaceuticals.md) | total_equity | 20,907,400,000 United States dollar | valid 2026-09-30 to present | conf 0.95 | valid | [clm_088E22D9B313](/claim/clm_088E22D9B313.md) sources: https://www.sec.gov/Archives/edgar/data/875320/000087532026000291/0000875320-26-000291-index.htm ## Ended (7) Held on 2025-11-10, not on 2026-11-10, and not replaced by another value. - [Vertex Pharmaceuticals](/record/vertex-pharmaceuticals.md) | cash_and_equivalents | 4,939,600,000 United States dollar | valid 2025-09-30 to 2025-12-31 | conf 0.95 | superseded | superseded_by [clm_B4475729CD2A](/claim/clm_B4475729CD2A.md) | [clm_2FB43E38D7CC](/claim/clm_2FB43E38D7CC.md) sources: https://www.sec.gov/Archives/edgar/data/875320/000087532025000232/0000875320-25-000232-index.htm - [Vertex Pharmaceuticals](/record/vertex-pharmaceuticals.md) | quarterly_net_income | 1,082,900,000 United States dollar | valid 2025-09-30 to 2026-03-31 | conf 0.95 | superseded | superseded_by [clm_58ABF4712193](/claim/clm_58ABF4712193.md) | [clm_2FE795B3AF8B](/claim/clm_2FE795B3AF8B.md) sources: https://www.sec.gov/Archives/edgar/data/875320/000087532025000232/0000875320-25-000232-index.htm - [Vertex Pharmaceuticals](/record/vertex-pharmaceuticals.md) | quarterly_operating_income | 1,186,200,000 United States dollar | valid 2025-09-30 to 2026-03-31 | conf 0.95 | superseded | superseded_by [clm_B8F364B1BB32](/claim/clm_B8F364B1BB32.md) | [clm_7EF8A5505C22](/claim/clm_7EF8A5505C22.md) sources: https://www.sec.gov/Archives/edgar/data/875320/000087532025000232/0000875320-25-000232-index.htm - [Vertex Pharmaceuticals](/record/vertex-pharmaceuticals.md) | quarterly_revenue | 3,076,400,000 United States dollar | valid 2025-09-30 to 2026-03-31 | conf 0.95 | superseded | superseded_by [clm_78B1FE0A2ECC](/claim/clm_78B1FE0A2ECC.md) | [clm_8AB184162D82](/claim/clm_8AB184162D82.md) sources: https://www.sec.gov/Archives/edgar/data/875320/000087532025000232/0000875320-25-000232-index.htm - [Vertex Pharmaceuticals](/record/vertex-pharmaceuticals.md) | shares_outstanding | 253,718,831 shares | valid 2025-10-31 to 2026-02-06 | conf 0.95 | superseded | superseded_by [clm_B7B98F7F000A](/claim/clm_B7B98F7F000A.md) | [clm_663C199EF289](/claim/clm_663C199EF289.md) sources: https://www.sec.gov/Archives/edgar/data/875320/000087532025000232/0000875320-25-000232-index.htm - [Vertex Pharmaceuticals](/record/vertex-pharmaceuticals.md) | total_assets | 24,862,300,000 United States dollar | valid 2025-09-30 to 2025-12-31 | conf 0.95 | superseded | superseded_by [clm_0090178AE4A5](/claim/clm_0090178AE4A5.md) | [clm_D95598CEB876](/claim/clm_D95598CEB876.md) sources: https://www.sec.gov/Archives/edgar/data/875320/000087532025000232/0000875320-25-000232-index.htm - [Vertex Pharmaceuticals](/record/vertex-pharmaceuticals.md) | total_equity | 17,318,800,000 United States dollar | valid 2025-09-30 to 2025-12-31 | conf 0.95 | superseded | superseded_by [clm_335F6E7CE9CE](/claim/clm_335F6E7CE9CE.md) | [clm_1E5EC8CA7B8E](/claim/clm_1E5EC8CA7B8E.md) sources: https://www.sec.gov/Archives/edgar/data/875320/000087532025000232/0000875320-25-000232-index.htm ## Unchanged 11 claims held on both days: agreement 1, cik 1, fiscal_year_end 1, headquarters 1, listed_on 1, quarterly_research_and_development 1, registrant_name 1, research_and_development 1, sic_industry 1, state_of_incorporation 1, ticker 1. ## Get this data - JSON: /v1/entities/vertex-pharmaceuticals/diff?from=2025-11-10&to=2026-11-10 - MCP: entity_diff(entity: "vertex-pharmaceuticals", from: "2025-11-10", to: "2026-11-10") - Entity twin: /record/vertex-pharmaceuticals.md · timeline: /timelines/vertex-pharmaceuticals.md --- AsOf is a temporal fact ledger: a structured, dated, sourced record of what is true and what changed, built for AI retrieval.